Mammalian lignans inhibit the growth of estrogen-independent human colon tumor cells. Gholami Z, Akhlaghi M. The effect of flaxseed on physical and mental fatigue in children and adolescents with overweight/obesity: a randomised controlled trial. Lucas EA, Wild RD, Hammond LJ, et al. View abstract. The phase IV clinical study analyzes what interactions people who take Flaxseed and Anastrozole have. What Are the Benefits of Flaxseed Oil Pills? Omega-3 fats are best known for improving heart health, but your body uses the essential fat to perform many vital functions, including the formation of cell membranes and the creation of hormones that control blood clotting, blood vessel function and inflammation. When considering the use of herbal supplements, seek the advice of your doctor. Flaxseed interacts with 583 drugs . Cancer Lett 2006;234:168-75. Yes: Flaxseed may interact with acetaminophen, certain antibiotics, estrogens, furosemide, Ketoprofen, diabetes medication, anticoagulants & Metoprolo. View abstract. Enterolactone is differently associated with estrogen receptor beta-negative and -positive breast cancer in a Swedish nested case-control study. Flaxseed oil also might decrease blood clotting. Walnuts - bone loss, joint pain. View abstract. A single copy of these materials may be reprinted for noncommercial personal use only. Thompson LU, Rickard SE, Orcheson LJ, Seidl MM. However, you should always talk to your primary care provider to discuss flaxseed oil dosage and safety before adding the plant oil to your daily routine. Medications taken by mouth (Oral drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider. Version: 5.01. prednisone, atorvastatin, rosuvastatin, simvastatin, ezetimibe, estradiol, Crestor, MiraLAX, Colace, docusate. Flaxseed is considered to be a goitrogen. Some people also take flaxseed to treat inflammatory diseases. information submitted for this request. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Atherosclerosis 1998;136:367-75. Reducing atherogenic risk in hyperlipemic humans with flaxseed supplementation: a preliminary report. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination. The evidence is mixed as to whether flaxseed or flaxseed oil has any effect on the prostate or the risk of prostate cancer. Flaxseed oil, the most commonly used high risk supplement that contains phosphorus, was taken by 16 percent of patients with normal or mildly reduced kidney function. Flaxseed oil might lower blood pressure. Flaxseed is a good source of dietary fiber. Ramon JM, Bou R, Romea S, et al. 2021;60(1):287-298. Sun J, Bai H, Ma J, et al. Even though the nutritional profile of flaxseeds may be useful for improving the function of the Thyroid, it is important to consider that there is also one particular concerning the fact that need to be taken into account. 4. Salmon, wild - bone loss, joint pain. One tablespoon of flaxseed oil has 7.26 grams. 2013 May;33(5):367-75. Adolescent dietary phytoestrogen intake and breast cancer risk (Canada). Flax and flaxseed oil: An ancient medicine and modern functional food. View abstract. 2013 Apr;16(4):357-60. Am J Clin Nutr 2004;79:318-25.. View abstract. Because of the potential for flaxseed oil side effects and drug interactions, you should talk to your primary care provider before regularly supplementing your diet with the plant oil. You can get the same amount of omega-3 fatty acids in your body by consuming fewer fish oil capsules. Pan A, Sun J, Chen Y, et al. February 23, 2023. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Copyright 1996-2023 Cerner Multum, Inc. Am J Clin Nutr 1994;60:122-8. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Savas BB, Alparslan GB, Korkmaz C. Effect of flaxseed poultice compress application on pain and hand functions of patients with hand osteoarthritis. . Flaxseed might lower blood sugar levels. Anticancer Res 1998;18:1405-8. View abstract. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Systemic lupus erythematosus (SLE) nephritis, Constipation. How to Do the Front Foot Elevated Split Squat for Size, Strength, and Athleticism. View abstract. Kolonel LN, Nomura AM, Cooney RV. Flaxseed - More Interactions. Flaxseed is high in soluble fiber and in lignans, which contain phytoestrogens. Our website services, content, and products are for informational purposes only. Br J Nutr 1993;69:443-53. According to Dr. Jaiswal, some of the common prescription and over-the-counter medications that interact with levothyroxine are: Antibiotics: ciprofloxacin, rifampin Seizure medications: phenytoin, fosphenytoin, and carbamazepine Antidepressants: amitriptyline, fluoxetine (2015). Discuss with your doctor the benefits of flaxseed oil for your health before trying it out. Flaxseed (Linum usitatissimum) and flaxseed oil, which comes from flaxseed, are rich sources of the essential fatty acid alpha-linolenic acid a heart-healthy omega-3 fatty acid. Learn about the medical uses, claims, and side effects of flaxseed. This means that flaxseed can help improve digestion and lower cholesterol levels, while flaxseed oil does not have these effects. You should consume water regularly if you use flax seeds as a supplement. Accessed Sept. 27, 2017. Therefore, using flaxseed oil to relieve your bowels will not have the same effect as using flax seeds. Rich in omega-3 fatty acids, flaxseed oil is gaining ground as a functional food with many potential health benefits. Flaxseed reduces some risk factors of cardiovascular disease. Variability in anticancer lignan levels in flaxseed. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. Flaxseed oil is generally cold pressed. Complement Ther Med. Allman, M. A., Pena, M. M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Consumption of a flaxseed-rich food is not more effective than a placebo in alleviating the climacteric symptoms of postmenopausal women. View abstract. Haggans CJ, Hutchins AM, Olson BA, et al. Nutr Rev. For this reason, it is critical to discuss possible interactions with Trulicity before you start treatment with it. View abstract. A total of 12 drugs are known to interact with green tea. Nutr J. Although not all side effects are known, flax is thought to be likely safe for most people when taken by mouth. The effect of flaxseed supplementation on body weight and ody composition: a systematic review and meta-analysis of 45 randomized placebo-controlled trials. 016 Sep 1;21:70. Flaxseed is used for constipation, diabetes, high cholesterol, obesity, and swelling of the kidneys in people with lupus. 5 Science-Based Benefits of 5-HTP (Plus Dosage and Side Effects), The 15 Best Vitamin Brands of 2023: A Dietitians Picks, Red Raspberry Leaf Tea: Pregnancy, Benefits, and Side Effects. Ibrgger S, Kristensen M, Mikkelsen MS, Astrup A. Flaxseed dietary fiber supplements for suppression of appetite and food intake. Int J Prev Med. A September 2014 article published in the Journal of Food Science and Technology says flaxseed oil is the best plant source of the essential fat. The effect of flaxseed and wheat bran consumption on urinary estrogen metabolites in premenopausal women. Does Flaxseed Interact with other Medications? Mirghafourvand M, Mohammad-Alizadeh-Charandabi S, Ahmadpour P, Javadzadeh Y. Cotterchio M, Boucher BA, Manno M, et al. Effects of a flaxseed-derived lignan supplement in type 2 diabetic patients: a randomized, double-blind, cross-over trial. There are 10 disease interactions with Cymbalta (duloxetine) which include: Liver Disease Renal Disease Depression Diabetes Glaucoma Hypertension Hyponatremia Mania Seizures Urinary Tract Obstruction Is it safe to eat raw flaxseed during pregnancy? Most of the health benefits associated with omega-3 fatty acids from improving heart health to reducing inflammation are due to EPA and DHA, which come from fish and fish oil. Flaxseed in lupus nephritis: a two-year nonplacebo-controlled crossover study. Plasma enterolignan concentrations and colorectal cancer risk in a nested case-control study. 2019;97(6):557-561. Flaxseed oil contains a-linolenic acid (ALA), which the body can break down into an omega-3 fatty acid. Meta-analysis of the effects of flaxseed interventions on blood lipids. Prasad K. Dietary flax seed in prevention of hypercholesterolemic atherosclerosis. Ann N Y Acad Sci 1990;595:281-90. Though your body can make many types of fat on its own, such as cholesterol, omega-3 fatty acids are essential and must be supplied from outside sources. Flaxseed is an herbal supplement used to treat constipation (chronic), enlarged prostate (oil), cancer (prevention), diabetes, diverticulitis, inflammation of the small intestine and/or the stomach, high cholesterol, irritable bowel syndrome, menopausal symptoms, myocardial infarction prevention (oil), skin inflammation, and systemic lupus Flaxseed oil might lower blood pressure. Beta . Nutr Cancer 1999;33:188-95. Wang L, Chen J, Thompson LU. Alonso L, Marcos ML, Blanco JG, et al. Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose-response meta-analysis of randomized controlled trials. Answer: Atorvastatin (Lipitor), rosuvastatin (Crestor), and other cholesterol-lowering statin drugs can be affected by taking supplements and can affect your ability to absorb certain vitamins and minerals. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Polypodium Leucotomos - Inotersen. While some studies support health claims, most are small, and more research is needed. Flaxseed consumption reduces blood pressure in patients with hypertension by altering circulating oxylipins via an a-linolenic acid-induced inhibition of soluble epoxide hydrolase. J Res Med Sci. View abstract. View abstract. View abstract. View abstract. (2013). To be as proactive as possible, consult your doctor about using flaxseed oil as a dietary supplement before you begin to use it. Khandouzi N, Zahedmehr A, Mohammadzadeh A, Sanati HR, Nasrollahzadeh J. Reprod Toxicol 2007;23:397-406. Oncology Nutrition advises that you should discuss the use of flax seeds with your doctor and avoid the use of flaxseed oil altogether because it provides no benefit to those with prostate cancer. Leon F, Rodriguez M, Cuevas M. Anaphylaxis to Linum. J Altern Complement Med 2020;26(9):799-806. You need to be careful in using these supplements if you have diabetes or any other condition that affects your blood sugar levels. View abstract. Adlercreutz H, Fotsis T, Bannwart C, et al. 2016 Feb;25:90-5. Circulating enterolactone and risk of endometrial cancer. Haghighatsiar N, Askari G, Saraf-Bank S, Feizi A, Keshmiri H. Effect of flaxseed powder on cardiovascular risk factor in dyslipidemic and hypertensive patients. Research on the use of flaxseed and flaxseed oil for specific conditions shows: When used in combination with daily exercise and a low cholesterol diet, flaxseed might help control cholesterol levels. View abstract. J Clin Endocrinol Metab 2002;87:1527-32.. View abstract. Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer. Demark-Wahnefried W, Price DT, Polascik TJ, et al. High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans. Blood pressure drugs, herbs and supplements. This means that flaxseed can help improve digestion and lower cholesterol levels, while flaxseed oil does not have these effects. J Am Coll Nutr 2008;27:65-74. View abstract. Moreover, the National Center for Biotechnology Information shared an article from the Division of Natural Products, which is a branch of the Food and Drug Administration, agreeing with the dangers that flaxseed can have on the . Though flaxseed oil benefits your blood pressure, if you take blood pressure medication and supplement your diet regularly with flaxseed oil, the combination may lower your blood pressure too much. View abstract. How fast does psyllium work? J Am Coll Nutr 2001;20:398S-402S. For many, the benefits of flax seeds and flaxseed oil may outweigh the risks of using the product. Saw palmetto Saw palmetto might make your risk of bleeding higher if you also take a blood thinner, such as: Aspirin Clopidogrel Warfarin St. John's wort Please contact your doctor or pharmacist. Flax should not be used in place of medication prescribed for you by your doctor. However, it may cause undesirable side effects if you have a preexisting medical condition, use certain medications, or take the wrong dosage. 2013 Aug 1;167(8):708-13. 2014;22:43. Flaxseed oil may interact with some medications including blood thinners, cholesterol-lowering statins, and diabetes medications.. The inhibitory effect of flaxseed on the growth and metastasis of estrogen receptor negative human breast cancer xenografts is attributed to both its lignan and oil components. Anaphylaxis caused by flaxseed. Flaxseeds are high in potassium. Stop using flax and call your healthcare provider at once if you have: bloating, gas, stomach ache, constipation, diarrhea, and nausea. Read more: What Are the Benefits of Flaxseed Oil Pills? View abstract. View abstract. Touillaud MS, Thiebaut AC, Fournier A, et al. Low adherence may be a contributing factor leading to uncontrolled blood pressure in patients. are using nonsteroidal anti-inflammatory drugs. Your body is an amazing physiological machine. 2005 - 2023 WebMD LLC. It is not intended to replace professional veterinary advice or care. Do not take flax without medical advice if you are using any of the following medications: any medications for diabetes or high blood pressure; This list is not complete. Am J Epidemiol 2007;165:514-23. Exp Biol Med (Maywood) 2007;232:1071-80. Sung MK, Lautens M, Thompson LU. information is beneficial, we may combine your email and website usage information with 2016 Jun;67(4):461-9. OTHER NAME(S): Alasi, Aliviraaii, Brown Flaxseed, Brown-Seeded Fl, Flax (Linum usitatissimum) is a food and fiber crop. Cancer Epidemiol Biomarkers Prev 2000;9:719-25. Blood Pressure Medication That Cause Coughing. Zhang W, Wang X, Liu Y, et al. Urinary lignan and isoflavonoid excretion in premenopausal women consuming flaxseed powder. Cotterchio M, Boucher BA, Kreiger N, et al. Appl Physiol Nutr Metab 2009;34:89-98. Flaxseed dietary supplement versus hormone replacement therapy in hypercholesterolemic menopausal women. Learn about the medical uses, claims, and side effects of flaxseed. See if Ritual products are right, It's no secret that vitamins can improve your health, but not all vitamins and minerals are created equal. Raspberries - joint pain. Int J Cancer 2006;119:2376-81. Moderate to vigorous physical activity, particularly aerobic exercise, has been shown to be associated with lower risk of bone fractures in women being treated with aromatase inhibitors. Here are 5 potential benefits of 5-HTP, Ritual is a subscription-based vitamin company that offers protein powders and multivitamins for people of all ages. These medications are not usually taken together. Ann Nutr Metab 2000;44:263-5. These might be signs of anaphylactic shock. other information we have about you. Obes Facts 2022. You should also be cautious about consuming flaxseed oil if you use medications that alter your blood sugar levels. J Nutr 2004;134:919-22. View abstract. Rodriguez-Leyva D, Rodriguez-Portelles A, Weighell W, Guzman R, Maddaford TG, Pierce GN. View abstract. Is Flaxseed Good for Thyroid? Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Advertising and sponsorship opportunities. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Cancer Epidemiol Biomarkers Prev 2000;9:335-8. J Nutr. This might alter the effects of flaxseed. Clin Nutr ESPEN. Flaxseed and prostate cancer risk. Using different formulations together increases the risk of an overdose. Am J Clin Nutr 2004;80:204-16. Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. Demark-Wahnefried W, Polascik TJ, George SL, et al. If you have a condition or take a medication that lowers your blood pressure, adding this supplement to your diet could cause complications. Monitor your blood pressure closely. Many people take fish oil supplements daily, but you may not know whats the right dosage for you. Dodin S, Lemay A, Jacques H, et al. Flaxseed. J Steroid Biochem Mol Biol 1992;41:615-9.. View abstract. However, whether flaxseed oil benefits your health is still under debate, according to the National Center for Complementary and Integrative Health (NCCIH). Cancer Epidemiol Biomarkers Prev 2008;17:3241-51. View abstract. A prospective study of polyunsaturated fatty acid levels in blood and prostate cancer risk. View abstract. 2019;38(7):1961-1969. Medicinal use of this product has not been approved by the FDA. Fitzpatrick says new research also suggests significant blood pressure-lowering effects of flaxseed.